Study examines link between immune dysfunction and metabolism in ME

Dr Christopher Armstrong and Fane Mensah standing together, wearing suits and ties,

By Sasha Nimmo An international collaboration of scientists, including Fane Mensah, Dr Jo Cambridge and Australian Dr Chris Armstrong investigated the relationship between CD24 expression and B cell maturation and found CD24 expression on B cells is related to energy metabolism and that its role differs between B cell subsets. ‘CD24 Expression and B Cell … Continue reading Study examines link between immune dysfunction and metabolism in ME

Impaired intracellular calcium transfer affecting Natural Killer cells in ME

Bar graphs representing TRPM3 current amplitude at + 100 mV after stimulation with 100 μΜ PregS in CFS/ME patients at just over 5. Healthy controls at around 12.5

by Sasha Nimmo Australian scientists at the National Centre for Neuroimmunlogy and Emerging Diseases at Griffith University published a new paper on reduced intracellular calcium mobilisation in Natural Killer (NK) immune cells and Transient Receptor Potential Melastatin 3 (TRPM3) cation channels. Authors say it 'could suggest potential therapeutic targets and/or prognostic markers'. 'Loss of Transient Receptor … Continue reading Impaired intracellular calcium transfer affecting Natural Killer cells in ME

Study finds reduced ability to respond to energy demands in ME patients’ immune systems

figures C,D,E showing lower levels in glycolysis compared to controls

by Sasha Nimmo Scientists from Australia's Griffith University found 'a significant reduction of glycolytic reserve in resting natural killer (NK) cells' from people with Myalgic Encephalomyelitis (ICC ME) compared with healthy controls. "These findings suggest resting NK cells from ME/CFS patients have reduced ability to increase glycolytic flux to respond to high energetic demands for … Continue reading Study finds reduced ability to respond to energy demands in ME patients’ immune systems

Nature journal publishes metabolism study

diagram of increased and decreased metabolites

by Sasha Nimmo A new study published in the prestigous journal, Nature, examined the metabolism of people with ME and/or chronic fatigue syndrome and looked at irritable bowel syndrome (IBS), finding differences between patients and controls as well as patient subgroups with and without IBS. It also confirmed earlier metabolic studies. The study, 'Insights into … Continue reading Nature journal publishes metabolism study

Brain differences shown in chronic fatigue syndrome (Fukuda) study

diagram showing more of the brain lit up compared to controls

by Sasha Nimmo Scientists at Queensland's National Centre for Neuroimmunology and Emerging Diseases, Griffith University found obvious differences between the brains of patients with chronic fatigue syndrome and healthy controls, when examined using magnetic resonance imaging (MRI) during an attention test. The study examined 43 people with chronic fatigue syndrome (Fukuda criteria) and 26 healthy … Continue reading Brain differences shown in chronic fatigue syndrome (Fukuda) study

Mason Foundation explores ME and CFS biobank for Australia

Proposed Mason Foundation research scheme diagram, listing the precentage of where money may go. Details in article.

By Sasha Nimmo Most of Australia's medical research funding for ME and CFS comes from the Mason Foundation, who are currently looking at whether they will fund a biobank or a patient registry for Myalgic Encephalomyelitis and/or chronic fatigue syndrome samples.  Last week the Mason Foundation updated stakeholders on the decision-making process. This is important … Continue reading Mason Foundation explores ME and CFS biobank for Australia